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Putting the Genome in Context : Gene-Environment Interactions in Type 2 Diabetes

  • Paul W. Franks
  • Guillaume Paré
Publishing year: 2016-07-01
Language: English
Publication/Series: Current Diabetes Reports
Volume: 16
Issue: 7
Document type: Journal article
Publisher: Current Science inc.

Abstract english

The genome is often the conduit through which environmental exposures convey their effects on health and disease. Whilst not all diseases act by directly perturbing the genome, the phenotypic responses are often genetically determined. Hence, whilst diseases are often defined has having differing degrees of genetic determination, genetic and environmental factors are, with few exceptions, inseparable features of most diseases, not least type 2 diabetes. It follows that to optimize diabetes, prevention and treatment will require that the etiological roles of genetic and environmental risk factors be jointly considered. As we discuss here, studies focused on quantifying gene-environment and gene-treatment interactions are gathering momentum and may eventually yield data that helps guide health-related choices and medical interventions for type 2 diabetes and other complex diseases.


  • Medical Genetics
  • Cardiometabolic
  • Gene-lifestyle interaction
  • Genomic
  • Genotype-based recall
  • Obesity
  • Recall by genotype
  • Systems biology
  • Variance heterogeneity


  • Genetic and Molecular Epidemiology
  • ISSN: 1534-4827
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49



Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00