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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Alcohol consumption and mortality in individuals with diabetes mellitus

Author

  • Diewertje Sluik
  • Heiner Boeing
  • Manuela M. Bergmann
  • Madlen Schuetze
  • Birgit Teucher
  • Rudolf Kaaks
  • Anne Tjonneland
  • Kim Overvad
  • Larraitz Arriola
  • Eva Ardanaz
  • Benedetta Bendinelli
  • Claudia Agnoli
  • Rosario Tumino
  • Fulvio Ricceri
  • Amalia Mattiello
  • Annemieke M. W. Spijkerman
  • Joline W. J. Beulens
  • Diederick E. Grobbee
  • Peter Nilsson
  • Olle Melander
  • Paul Franks
  • Olov Rolandsson
  • Elio Riboli
  • Valentina Gallo
  • Dora Romaguera
  • Ute Noethlings

Summary, in English

Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (>0-6 g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6 g/d or more and total mortality. HR for >6.12 g/d was 0.89(95% CI 0.61, 1.30) in men and 0.86(95% CI 0.46, 1.60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1.52 (95% CI 0.99, 2.35) in men and 1.81 (95% CI 1.04, 3.17) in women. The present study in diabetic individuals showed no association between current alcohol consumption >6 g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence.

Department/s

  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Genetic and Molecular Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

1307-1315

Publication/Series

British Journal of Nutrition

Volume

108

Issue

7

Document type

Journal article

Publisher

Cambridge University Press

Topic

  • Nutrition and Dietetics

Keywords

  • Diabetes mellitus
  • Alcohol consumption
  • History of alcohol consumption
  • Mortality

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 1475-2662