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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Author

  • Luca A. Lotta
  • Pawan Gulati
  • Felix R Day
  • Felicity Payne
  • Halit Ongen
  • Martijn van de Bunt
  • Kyle J Gaulton
  • John D. Eicher
  • Stephen J. Sharp
  • Jian'an Luan
  • Emanuella De Lucia Rolfe
  • Isobel D. Stewart
  • Eleanor Wheeler
  • Sara M Willems
  • Claire Adams
  • Hanieh Yaghootkar
  • Stephen J. Sharp
  • Nita G. Forouhi
  • Nicola D. Kerrison
  • Matt Sims
  • Debora M E Lucarelli
  • Panos Deloukas
  • Mark I. McCarthy
  • Larraitz Arriola
  • Beverley Balkau
  • Aurelio Barricarte
  • Heiner Boeing
  • Paul W. Franks
  • Carlos Gonzalez
  • Sara Grioni
  • Rudolf Kaaks
  • Timothy J Key
  • Carmen Navarro
  • Peter M. Nilsson
  • Kim Overvad
  • Domenico Palli
  • Salvatore Panico
  • J Ramón Quirós
  • Olov Rolandsson
  • Carlotta Sacerdote
  • Elena Salamanca-Fernández
  • Nadia Slimani
  • Anne Tjonneland
  • Rosario Tumino
  • Annemieke M. W. Spijkerman
  • Daphne L. van der A
  • Yvonne T. van der Schouw
  • Elio Riboli
  • Robert K Semple
  • Anna Stears

Summary, in English

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link with higher cardiometabolic risk is underpinned by an association with lower adipose mass in peripheral compartments. Using these 53 loci, we show a polygenic contribution to familial partial lipodystrophy type 1, a severe form of insulin resistance, and highlight shared molecular mechanisms in common/mild and rare/severe insulin resistance. Population-level genetic analyses combined with experiments in cellular models implicate CCDC92, DNAH10 and L3MBTL3 as previously unrecognized molecules influencing adipocyte differentiation. Our findings support the notion that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.

Department/s

  • Genetic and Molecular Epidemiology
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017-01-01

Language

English

Pages

17-26

Publication/Series

Nature Genetics

Volume

49

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Endocrinology and Diabetes
  • Medical Genetics

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 1061-4036