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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.

Author

  • Paul Franks
  • Alaitz Poveda

Summary, in English

Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of the published literature on gene x lifestyle (physical activity and dietary factors) and gene x drug interactions in relation to obesity. Finally, we overview the scope and findings from these studies and discuss some of their strengths and limitations.

Department/s

  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

401-456

Publication/Series

Current Vascular Pharmacology

Volume

9

Issue

4

Document type

Journal article

Publisher

Bentham Science Publishers

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • gene x drug interaction
  • Genetic
  • gene x lifestyle interaction
  • nutrition
  • nutriogenomics
  • obesity
  • pharmacogenetics
  • physical activity

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1570-1611