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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

  • Robert Koivula
  • Alison Heggie
  • Anna Barnett
  • Henna Cederberg
  • Tue H Hansen
  • Anitra D Koopman
  • Martin Ridderstråle
  • Femke Rutters
  • Henrik Vestergaard
  • Ramneek Gupta
  • Sanna Herrgård
  • Martijn W Heymans
  • Mandy H Perry
  • Simone Rauh
  • Maritta Siloaho
  • Harriet J A Teare
  • Barbara Thorand
  • Jimmy Bell
  • Søren Brunak
  • Gary Frost
  • Bernd Jablonka
  • Andrea Mari
  • Tim J McDonald
  • Jacqueline M Dekker
  • Torben Hansen
  • Andrew Hattersley
  • Markku Laakso
  • Oluf Pedersen
  • Veikko Koivisto
  • Hartmut Ruetten
  • Mark Walker
  • Ewan Pearson
  • Paul Franks
Publishing year: 2014
Language: English
Pages: 1132-1142
Publication/Series: Diabetologia
Volume: 57
Issue: 6
Document type: Journal article
Publisher: Springer Verlag

Abstract english

The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.


  • Endocrinology and Diabetes


  • Genetic and Molecular Epidemiology
  • Clinical Obesity
  • ISSN: 1432-0428
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49



Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00