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Paul Franks

Paul Franks

Principal investigator

Paul Franks

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Author

  • Georg B. Ehret
  • Teresa Ferreira
  • Daniel I. Chasman
  • Anne U. Jackson
  • Ellen M. Schmidt
  • Toby Johnson
  • Gudmar Thorleifsson
  • Jian'An Luan
  • Louise A. Donnelly
  • Stavroula Kanoni
  • Ann Kristin Petersen
  • Vasyl Pihur
  • Rona J. Strawbridge
  • Dmitry Shungin
  • Maria F. Hughes
  • Osorio Meirelles
  • Marika Kaakinen
  • Nabila Bouatia-Naji
  • Kati Kristiansson
  • Sonia Shah
  • Marcus E. Kleber
  • Xiuqing Guo
  • Leo Pekka Lyytikäinen
  • Cristiano Fava
  • Niclas Eriksson
  • Ilja M. Nolte
  • Patrik K. Magnusson
  • Elias L. Salfati
  • Loukianos S. Rallidis
  • Elizabeth Theusch
  • Andrew J P Smith
  • Lasse Folkersen
  • Kate Witkowska
  • Tune H. Pers
  • Roby Joehanes
  • Stuart K. Kim
  • Lazaros Lataniotis
  • Rick Jansen
  • Andrew D. Johnson
  • Helen Warren
  • Young Jin Kim
  • Wei Zhao
  • Ying Wu
  • Bamidele O. Tayo
  • Murielle Bochud
  • Devin Absher
  • Linda S. Adair
  • Najaf Amin
  • Dan E. Arking
  • Tomas Axelsson
  • Damiano Baldassarre
  • Beverley Balkau
  • Stefania Bandinelli
  • Michael R. Barnes
  • Inês Barroso
  • Stephen Bevan
  • Joshua C. Bis
  • Gyda Bjornsdottir
  • Michael Boehnke
  • Eric Boerwinkle
  • Lori L. Bonnycastle
  • Dorret I. Boomsma
  • Stefan R. Bornstein
  • Morris J. Brown
  • Michel Burnier
  • Claudia P. Cabrera
  • John C. Chambers
  • I. Shou Chang
  • Ching Yu Cheng
  • Peter S. Chines
  • Ren Hua Chung
  • Francis S. Collins
  • John M. Connell
  • Angela Döring
  • Jean Dallongeville
  • John Danesh
  • Ulf De Faire
  • Graciela Delgado
  • Anna F. Dominiczak
  • Alex S F Doney
  • Fotios Drenos
  • Sarah Edkins
  • John D. Eicher
  • Roberto Elosua
  • Stefan Enroth
  • Jeanette Erdmann
  • Per Eriksson
  • Tonu Esko
  • Evangelos Evangelou
  • Alun Evans
  • Tove Fall
  • Martin Farrall
  • Janine F. Felix
  • Jean Ferrières
  • Luigi Ferrucci
  • Myriam Fornage
  • Terrence Forrester
  • Nora Franceschini
  • Oscar H. Franco
  • Anders Franco-Cereceda
  • Ross M. Fraser
  • Santhi K. Ganesh
  • He Gao
  • Karl Gertow
  • Francesco Gianfagna
  • Bruna Gigante
  • Franco Giulianini
  • Anuj Goel
  • Alison H. Goodall
  • Mark O. Goodarzi
  • Mathias Gorski
  • Jürgen Gräßler
  • Christopher J. Groves
  • Vilmundur Gudnason
  • Ulf Gyllensten
  • Göran Hallmans
  • Anna Liisa Hartikainen
  • Maija Hassinen
  • Aki S. Havulinna
  • Caroline Hayward
  • Serge Hercberg
  • Karl Heinz Herzig
  • Andrew A. Hicks
  • Aroon D. Hingorani
  • Joel N. Hirschhorn
  • Albert Hofman
  • Jostein Holmen
  • Oddgeir Lingaas Holmen
  • Jouke Jan Hottenga
  • Phil Howard
  • Chao A. Hsiung
  • Steven C. Hunt
  • M. Arfan Ikram
  • Thomas Illig
  • Carlos Iribarren
  • Richard A. Jensen
  • Mika Kähönen
  • Hyun Min Kang
  • Sekar Kathiresan
  • Brendan J. Keating
  • Kay Tee Khaw
  • Yun Kyoung Kim
  • Eric Kim
  • Mika Kivimaki
  • Norman Klopp
  • Genovefa Kolovou
  • Pirjo Komulainen
  • Jaspal S. Kooner
  • Gulum Kosova
  • Ronald M. Krauss
  • Diana Kuh
  • Zoltan Kutalik
  • Johanna Kuusisto
  • Kirsti Kvaløy
  • Timo A. Lakka
  • Nanette R. Lee
  • I. Te Lee
  • Wen Jane Lee
  • Daniel Levy
  • Xiaohui Li
  • Kae Woei Liang
  • Honghuang Lin
  • Li Lin
  • Jaana Lindström
  • Stéphane Lobbens
  • Satu Männistö
  • Gabriele Müller
  • Martina Müller-Nurasyid
  • François Mach
  • Hugh S. Markus
  • Eirini Marouli
  • Mark I. McCarthy
  • Colin A. McKenzie
  • Pierre Meneton
  • Cristina Menni
  • Andres Metspalu
  • Vladan Mijatovic
  • Leena Moilanen
  • May E. Montasser
  • Andrew D. Morris
  • Alanna C. Morrison
  • Antonella Mulas
  • Ramaiah Nagaraja
  • Narisu Narisu
  • Kjell Nikus
  • Christopher J. O'Donnell
  • Paul F. O'Reilly
  • Ken K. Ong
  • Fred Paccaud
  • Cameron D. Palmer
  • Afshin Parsa
  • Nancy L. Pedersen
  • Brenda W. Penninx
  • Markus Perola
  • Annette Peters
  • Neil Poulter
  • Peter P. Pramstaller
  • Bruce M. Psaty
  • Thomas Quertermous
  • Dabeeru C. Rao
  • Asif Rasheed
  • N. William Rayner
  • Frida Renström
  • Rainer Rettig
  • Kenneth M. Rice
  • Robert Roberts
  • Lynda M. Rose
  • Jacques Rossouw
  • Nilesh J. Samani
  • Serena Sanna
  • Jouko Saramies
  • Heribert Schunkert
  • Sylvain Sebert
  • Wayne H H Sheu
  • Young Ah Shin
  • Xueling Sim
  • Johannes H. Smit
  • Albert V. Smith
  • Maria X. Sosa
  • Tim D. Spector
  • Alena Stančáková
  • Alice V. Stanton
  • Kathleen E. Stirrups
  • Heather M. Stringham
  • Johan Sundstrom
  • Amy J. Swift
  • Ann Christine Syvänen
  • E. Shyong Tai
  • Toshiko Tanaka
  • Kirill V. Tarasov
  • Alexander Teumer
  • Unnur Thorsteinsdottir
  • Martin D. Tobin
  • Elena Tremoli
  • Andre G. Uitterlinden
  • Matti Uusitupa
  • Ahmad Vaez
  • Dhananjay Vaidya
  • Cornelia M. Van Duijn
  • Erik P A Van Iperen
  • Ramachandran S. Vasan
  • Germaine C. Verwoert
  • Jarmo Virtamo
  • Veronique Vitart
  • Benjamin F. Voight
  • Peter Vollenweider
  • Aline Wagner
  • Louise V. Wain
  • Nicholas J. Wareham
  • Hugh Watkins
  • Alan B. Weder
  • Harm Jan Westra
  • Rainford Wilks
  • Tom Wilsgaard
  • James F. Wilson
  • Tien Y. Wong
  • Tsun Po Yang
  • Jie Yao
  • Loic Yengo
  • Weihua Zhang
  • Jing Hua Zhao
  • Xiaofeng Zhu
  • Pascal Bovet
  • Richard S. Cooper
  • Karen L. Mohlke
  • Danish Saleheen
  • Jong Young Lee
  • Paul Elliott
  • Hinco J. Gierman
  • Cristen J. Willer
  • Lude Franke
  • G. Kees Hovingh
  • Kent D. Taylor
  • George Dedoussis
  • Peter Sever
  • Andrew Wong
  • Lars Lind
  • Themistocles L. Assimes
  • Inger Njølstad
  • Peter E H Schwarz
  • Claudia Langenberg
  • Harold Snieder
  • Mark J. Caulfield
  • Olle Melander
  • Markku Laakso
  • Juha Saltevo
  • Rainer Rauramaa
  • Jaakko Tuomilehto
  • Erik Ingelsson
  • Terho Lehtimäki
  • Kristian Hveem
  • Walter Palmas
  • Winfried März
  • Meena Kumari
  • Veikko Salomaa
  • Yii Der I Chen
  • Jerome I. Rotter
  • Philippe Froguel
  • Marjo Riitta Jarvelin
  • Edward G. Lakatta
  • Kari Kuulasmaa
  • Paul W. Franks
  • Anders Hamsten
  • H. Erich Wichmann
  • Colin N A Palmer
  • Kari Stefansson
  • Paul M. Ridker
  • Ruth J F Loos
  • Aravinda Chakravarti
  • Panos Deloukas
  • Andrew P. Morris
  • Christopher Newton-Cheh
  • Patricia B. Munroe

Summary, in English

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.

Department/s

  • Genetic and Molecular Epidemiology
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016-10-01

Language

English

Pages

1171-1184

Publication/Series

Nature Genetics

Volume

48

Issue

10

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Medical Genetics

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 1061-4036