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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus

Author

  • Shannon D. Sullivan
  • Kathleen A. Jablonski
  • Jose C. Florez
  • Dana Dabelea
  • Paul W. Franks
  • Sam Dagogo-Jack
  • Catherine Kim
  • William C. Knowler
  • Costas A. Christophi
  • Robert Ratner

Summary, in English

OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS: We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS: β-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS: These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to β-cell dysfunction.

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Genetic and Molecular Epidemiology

Publishing year

2014-01-01

Language

English

Pages

909-911

Publication/Series

Diabetes Care

Volume

37

Issue

4

Document type

Journal article

Publisher

American Diabetes Association

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 0149-5992