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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Cognitive Function in Young Men and the Later Risk of Fractures

Author

  • Peter Nordstrom
  • Paul Franks
  • Yngve Gustafson
  • Anna Nordstrom

Summary, in English

Dementia has been associated with an increased risk of fractures. These associations may be explained by an impaired cognitive function, as well as comorbid illness and toxic reaction from drugs. To investigate whether cognitive function in young, healthy individuals already affects the risk of fractures, overall cognitive function scores were calculated from four cognitive tests accomplished during a national conscriptions test in 960,956 men with a mean age of 18 years. Incident fractures were searched in national registers. During a median follow-up of 30 years (range 0 to 41 years), 65,313 men had one fracture and 2589 men had a hip fracture. Compared with men with no fracture, overall cognitive function at baseline was 3.5% lower for men sustaining one fracture and 5.5% lower for men sustaining a hip fracture (p<0.001 for both). When comparing the lowest and the highest decile, low overall cognitive function scores increased the risk one fracture (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.50-1.61) and a hip fracture (HR 2.12, 95% CI 1.77-2.55), after adjustment for confounders. A higher education (university level versus elementary school) was associated with a decreased risk of a fracture (HR 0.67, 95% CI 0.65-0.69) and a hip fracture (HR 0.51, 95% CI 0.45-0.57). The effects of education and cognitive function were reduced when also adjusting for total income and disability pension. In summary, low cognitive function and education in young men were associated with the later risk of especially hip fractures. These associations may partly be mediated by socioeconomic factors. (C) 2012 American Society for Bone and Mineral Research.

Department/s

  • Genetic and Molecular Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

2291-2297

Publication/Series

Journal of Bone and Mineral Research

Volume

27

Issue

11

Document type

Journal article

Publisher

AMBMR

Topic

  • Endocrinology and Diabetes

Keywords

  • FRACTURES
  • HIP FRACTURES
  • COGNITIVE FUNCTION
  • EDUCATION
  • MEN

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 1523-4681