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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

Author

  • C. Langenberg
  • S. Sharp
  • N. G. Forouhi
  • Paul Franks
  • M. B. Schulze
  • N. Kerrison
  • U. Ekelund
  • I. Barroso
  • S. Panico
  • M. J. Tormo
  • J. Spranger
  • S. Griffin
  • Y. T. van der Schouw
  • P. Amiano
  • E. Ardanaz
  • L. Arriola
  • B. Balkau
  • A. Barricarte
  • J. W. J. Beulens
  • H. Boeing
  • H. B. Bueno-de-Mesquita
  • B. Buijsse
  • M. D. Chirlaque Lopez
  • F. Clavel-Chapelon
  • F. L. Crowe
  • B. de Lauzon-Guillan
  • P. Deloukas
  • M. Dorronsoro
  • D. Drogan
  • P. Froguel
  • C. Gonzalez
  • S. Grioni
  • Leif Groop
  • C. Groves
  • P. Hainaut
  • J. Halkjaer
  • G. Hallmans
  • T. Hansen
  • J. M. Huerta Castano
  • R. Kaaks
  • T. J. Key
  • K. T. Khaw
  • A. Koulman
  • A. Mattiello
  • C. Navarro
  • P Nilsson
  • T. Norat
  • K. Overvad
  • L. Palla
  • D. Palli
  • O. Pedersen
  • P. H. Peeters
  • J. R. Quiros
  • A. Ramachandran
  • L. Rodriguez-Suarez
  • O. Rolandsson
  • D. Romaguera
  • I. Romieu
  • C. Sacerdote
  • M. J. Sanchez
  • A. Sandbaek
  • N. Slimani
  • I. Sluijs
  • A. M. W. Spijkerman
  • B. Teucher
  • A. Tjonneland
  • R. Tumino
  • D. L. van der A
  • W. M. M. Verschuren
  • J. Tuomilehto
  • E. Feskens
  • M. McCarthy
  • E. Riboli
  • N. J. Wareham

Summary, in English

Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age. InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Genetic and Molecular Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

2272-2282

Publication/Series

Diabetologia

Volume

54

Issue

9

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Keywords

  • Cohort studies
  • Diabetes mellitus
  • Epidemiologic research design
  • Gene-lifestyle interaction
  • Genetic epidemiology
  • Type 2 diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 1432-0428