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Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts

  • Louise Brunkwall
  • Yan Chen
  • George Hindy
  • Gull Rukh
  • Ulrika Ericson
  • Ines E. Barroso
  • Ingegerd Johansson
  • Paul W. Franks
  • Marju Orho-Melander
  • Frida Renström
Publishing year: 2016-09-01
Language: English
Pages: 809-815
Publication/Series: American Journal of Clinical Nutrition
Volume: 104
Issue: 3
Document type: Journal article
Publisher: American Society for Clinical Nutrition

Abstract english

Background: The consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain. Objective: Common genetic susceptibility to obesity has been shown to modify the association between SSB intake and obesity risk in 3 prospective cohorts from the United States. We aimed to replicate these findings in 2 large Swedish cohorts. Design: Data were available for 21,824 healthy participants from the Malmö Diet and Cancer study and 4902 healthy participants from the Gene-Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk Study. Self-reported SSB intake was categorized into 4 levels (seldom, low, medium, and high). Unweighted and weighted genetic risk scores (GRSs) were constructed based on 30 body mass index [(BMI) in kg/m2]- Associated loci, and effect modification was assessed in linear regression equations by modeling the product and marginal effects of the GRS and SSB intake adjusted for age-, sex-, and cohort-specific covariates, with BMI as the outcome. In a secondary analysis, models were additionally adjusted for putative confounders (total energy intake, alcohol consumption, smoking status, and physical activity). Results: In an inverse variance-weighted fixed-effects metaanalysis, each SSB intake category increment was associated with a 0.18 higher BMI (SE = 0.02; P = 1.7 3 10220; n = 26,726). In the fully adjusted model, a nominal significant interaction between SSB intake category and the unweighted GRS was observed (P-interaction = 0.03). Comparing the participants within the top and bottom quartiles of the GRS to each increment in SSB intake was associated with 0.24 (SE = 0.04; P = 2.9 3 1028; n = 6766) and 0.15 (SE = 0.04; P = 1.3 3 1024; n = 6835) higher BMIs, respectively. Conclusions: The interaction observed in the Swedish cohorts is similar in magnitude to the previous analysis in US cohorts and indicates that the relation of SSB intake and BMI is stronger in people genetically predisposed to obesity. Am J Clin Nutr 2016;104:809-15.


  • Nutrition and Dietetics
  • Bmi
  • Gene-lifestyle interaction
  • Genetic risk score
  • Sugar-sweetened beverage
  • Sweden


  • Diabetes and cardiovascular disease - genetic epidemiolgy
  • Genetic and Molecular Epidemiology
  • ISSN: 0002-9165
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49



Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00