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Discovery and refinement of loci associated with lipid levels

Author:
  • Cristen J. Willer
  • Ellen M. Schmidt
  • Sebanti Sengupta
  • Gina M. Peloso
  • Stefan Gustafsson
  • Stavroula Kanoni
  • Andrea Ganna
  • Jin Chen
  • Martin L. Buchkovich
  • Samia Mora
  • Jacques S. Beckmann
  • Jennifer L. Bragg-Gresham
  • Hsing-Yi Chang
  • Ayse Demirkan
  • Heleen M. Den Hertog
  • Ron Do
  • Louise A. Donnelly
  • Georg B. Ehret
  • Tonu Esko
  • Mary F. Feitosa
  • Teresa Ferreira
  • Krista Fischer
  • Pierre Fontanillas
  • Ross M. Fraser
  • Daniel F. Freitag
  • Deepti Gurdasani
  • Kauko Heikkila
  • Elina Hyppoenen
  • Aaron Isaacs
  • Anne U. Jackson
  • Asa Johansson
  • Toby Johnson
  • Marika Kaakinen
  • Johannes Kettunen
  • Marcus E. Kleber
  • Xiaohui Li
  • Jian'an Luan
  • Leo-Pekka Lyytikainen
  • Patrik K. E. Magnusson
  • Massimo Mangino
  • Evelin Mihailov
  • May E. Montasser
  • Martina Mueller-Nurasyid
  • Ilja M. Nolte
  • Jeffrey R. O'Connell
  • Cameron D. Palmer
  • Markus Perola
  • Ann-Kristin Petersen
  • Serena Sanna
  • Richa Saxena
  • Susan K. Service
  • Sonia Shah
  • Dmitry Shungin
  • Carlo Sidore
  • Ci Song
  • Rona J. Strawbridge
  • Ida Surakka
  • Toshiko Tanaka
  • Tanya M. Teslovich
  • Gudmar Thorleifsson
  • Evita G. Van den Herik
  • Benjamin F. Voight
  • Kelly A. Volcik
  • Lindsay L. Waite
  • Andrew Wong
  • Ying Wu
  • Weihua Zhang
  • Devin Absher
  • Gershim Asiki
  • Ines Barroso
  • Latonya F. Been
  • Jennifer L. Bolton
  • Lori L. Bonnycastle
  • Paolo Brambilla
  • Mary S. Burnett
  • Giancarlo Cesana
  • Maria Dimitriou
  • Alex S. F. Doney
  • Angela Doering
  • Paul Elliott
  • Stephen E. Epstein
  • Gudmundur Ingi Eyjolfsson
  • Bruna Gigante
  • Mark O. Goodarzi
  • Harald Grallert
  • Martha L. Gravito
  • Christopher J. Groves
  • Goran Hallmans
  • Anna-Liisa Hartikainen
  • Caroline Hayward
  • Dena Hernandez
  • Andrew A. Hicks
  • Hilma Holm
  • Yi-Jen Hung
  • Thomas Illig
  • Michelle R. Jones
  • Pontiano Kaleebu
  • John J. P. Kastelein
  • Kay-Tee Khaw
  • Eric Kim
  • Norman Klopp
  • Pirjo Komulainen
  • Meena Kumari
  • Claudia Langenberg
  • Terho Lehtimaki
  • Shih-Yi Lin
  • Jaana Lindstrom
  • Ruth J. F. Loos
  • Francois Mach
  • Wendy L. McArdle
  • Christa Meisinger
  • Braxton D. Mitchell
  • Gabrielle Mueller
  • Ramaiah Nagaraja
  • Narisu Narisu
  • Tuomo V. M. Nieminen
  • Rebecca N. Nsubuga
  • Isleifur Olafsson
  • Ken K. Ong
  • Aarno Palotie
  • Theodore Papamarkou
  • Cristina Pomilla
  • Anneli Pouta
  • Daniel J. Rader
  • Muredach P. Reilly
  • Paul M. Ridker
  • Fernando Rivadeneira
  • Igor Rudan
  • Aimo Ruokonen
  • Nilesh Samani
  • Hubert Scharnagl
  • Janet Seeley
  • Kaisa Silander
  • Alena Stancakova
  • Kathleen Stirrups
  • Amy J. Swift
  • Laurence Tiret
  • Andre G. Uitterlinden
  • L. Joost van Pelt
  • Sailaja Vedantam
  • Nicholas Wainwright
  • Cisca Wijmenga
  • Sarah H. Wild
  • Gonneke Willemsen
  • Tom Wilsgaard
  • James F. Wilson
  • Elizabeth H. Young
  • Jing Hua Zhao
  • Linda S. Adair
  • Dominique Arveiler
  • Themistocles L. Assimes
  • Stefania Bandinelli
  • Franklyn Bennett
  • Murielle Bochud
  • Bernhard O. Boehm
  • Dorret I. Boomsma
  • Ingrid B. Borecki
  • Stefan R. Bornstein
  • Pascal Bovet
  • Michel Burnier
  • Harry Campbell
  • Aravinda Chakravarti
  • John C. Chambers
  • Yii-Der Ida Chen
  • Francis S. Collins
  • Richard S. Cooper
  • John Danesh
  • George Dedoussis
  • Ulf de Faire
  • Alan B. Feranil
  • Jean Ferrieres
  • Luigi Ferrucci
  • Nelson B. Freimer
  • Christian Gieger
  • Leif Groop
  • Vilmundur Gudnason
  • Ulf Gyllensten
  • Anders Hamsten
  • Tamara B. Harris
  • Aroon Hingorani
  • Joel N. Hirschhorn
  • Albert Hofman
  • G. Kees Hovingh
  • Chao Agnes Hsiung
  • Steve E. Humphries
  • Steven C. Hunt
  • Kristian Hveem
  • Carlos Iribarren
  • Marjo-Riitta Jarvelin
  • Antti Jula
  • Mika Kahonen
  • Jaakko Kaprio
  • Antero Kesaniemi
  • Mika Kivimaki
  • Jaspal S. Kooner
  • Peter J. Koudstaal
  • Ronald M. Krauss
  • Diana Kuh
  • Johanna Kuusisto
  • Kirsten O. Kyvik
  • Markku Laakso
  • Timo A. Lakka
  • Lars Lind
  • Cecilia M. Lindgren
  • Nicholas G. Martin
  • Winfried Maerz
  • Mark I. McCarthy
  • Colin A. McKenzie
  • Pierre Meneton
  • Andres Metspalu
  • Leena Moilanen
  • Andrew D. Morris
  • Patricia B. Munroe
  • Inger Njolstad
  • Nancy L. Pedersen
  • Chris Power
  • Peter P. Pramstaller
  • Jackie F. Price
  • Bruce M. Psaty
  • Thomas Quertermous
  • Rainer Rauramaa
  • Danish Saleheen
  • Veikko Salomaa
  • Dharambir K. Sanghera
  • Jouko Saramies
  • Peter E. H. Schwarz
  • Wayne H-H Sheu
  • Alan R. Shuldiner
  • Agneta Siegbahn
  • Tim D. Spector
  • Kari Stefansson
  • David P. Strachan
  • Bamidele O. Tayo
  • Elena Tremoli
  • Jaakko Tuomilehto
  • Matti Uusitupa
  • Cornelia M. van Duijn
  • Peter Vollenweider
  • Lars Wallentin
  • Nicholas J. Wareham
  • John B. Whitfield
  • Bruce H. R. Wolffenbuttel
  • Jose M. Ordovas
  • Eric Boerwinkle
  • Colin N. A. Palmer
  • Unnur Thorsteinsdottir
  • Daniel I. Chasman
  • Jerome I. Rotter
  • Paul Franks
  • Samuli Ripatti
  • L. Adrienne Cupples
  • Manjinder S. Sandhu
  • Stephen S. Rich
  • Michael Boehnke
  • Panos Deloukas
  • Sekar Kathiresan
  • Karen L. Mohlke
  • Erik Ingelsson
  • Goncalo R. Abecasis
Publishing year: 2013
Language: English
Pages: 1274-1274
Publication/Series: Nature Genetics
Volume: 45
Issue: 11
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and Endocrinology
  • Genetic and Molecular Epidemiology
  • ISSN: 1546-1718
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00