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Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program.

Author:
  • Paul Franks
  • Costas A Christophi
  • Kathleen A Jablonski
  • Liana K Billings
  • Linda M Delahanty
  • Edward S Horton
  • William C Knowler
  • Jose C Florez
Publishing year: 2014
Language: English
Pages: 485-490
Publication/Series: Diabetologia
Volume: 57
Issue: 3
Document type: Journal article
Publisher: Springer Verlag

Abstract english

PPARGC1A and PPARGCB encode transcriptional coactivators that regulate numerous metabolic processes. We tested associations and treatment (i.e. metformin or lifestyle modification) interactions with metabolic traits in the Diabetes Prevention Program, a randomised controlled trial in persons at high risk of type 2 diabetes.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Genetic and Molecular Epidemiology
  • ISSN: 1432-0428
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00