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LifeGene-a large prospective population-based study of global relevance

  • Catarina Almqvist
  • Hans-Olov Adami
  • Paul Franks
  • Leif Groop
  • Erik Ingelsson
  • Juha Kere
  • Lauren Lissner
  • Jan-Eric Litton
  • Markus Maeurer
  • Karl Michaelsson
  • Juni Palmgren
  • Goran Pershagen
  • Alexander Ploner
  • Patrick F. Sullivan
  • Gunnel Tybring
  • Nancy L. Pedersen
Publishing year: 2011
Language: English
Pages: 67-77
Publication/Series: European Journal of Epidemiology
Volume: 26
Issue: 1
Document type: Journal article
Publisher: Springer

Abstract english

Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.


  • Public Health, Global Health, Social Medicine and Epidemiology
  • Biobank
  • Cohort study
  • Epidemiology
  • Prospective study
  • Questionnaires
  • Population genetics


  • Diabetes and Endocrinology
  • ISSN: 1573-7284
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49



Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00