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Paul Franks

Paul Franks

Principal investigator

Paul Franks

Dairy product intake and risk of type 2 diabetes in EPIC-interact : A mendelian randomization study

Author

  • Linda E.T. Vissers
  • Ivonne Sluijs
  • Yvonne T. van der Schouw
  • Nita G. Forouhi
  • Fumiaki Imamura
  • Stephen Burgess
  • Aurelio Barricarte
  • Heiner Boeing
  • Catalina Bonet
  • Maria Dolores Chirlaque
  • Guy Fagherazzi
  • Paul W. Franks
  • Heinz Freisling
  • Marc J. Gunter
  • J. Ramón Quirós
  • Daniel B. Ibsen
  • Rudolf Kaaks
  • Timothy Key
  • Kay T. Khaw
  • Tilman Kühn
  • Olatz Mokoroa
  • Peter M. Nilsson
  • Kim Overvad
  • Valeria Pala
  • Domenico Palli
  • Salvatore Panico
  • Carlotta Sacerdote
  • Annemieke M.W. Spijkerman
  • Anne Tjonneland
  • Rosario Tumino
  • Miguel Rodríguez-Barranco
  • Olov Rolandsson
  • Elio Riboli
  • Stephen J. Sharp
  • Claudia Langenberg
  • Nicholas J. Wareham

Summary, in English


OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (b 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (b 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (b 27.0 g/day, 95% CI 212.4 to 21.7 per additional LP allele), nonalcoholic beverages (b 218.0 g/day, 95% CI 234.4 to 21.6), and wine (b 24.8 g/day, 95% CI 29.1 to 20.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio
per
15
g/day
0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.

Department/s

  • Genetic and Molecular Epidemiology
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Internal Medicine - Epidemiology

Publishing year

2019

Language

English

Pages

568-575

Publication/Series

Diabetes Care

Volume

42

Issue

4

Document type

Journal article

Publisher

American Diabetes Association

Topic

  • Endocrinology and Diabetes
  • Public Health, Global Health, Social Medicine and Epidemiology

Status

Published

Research group

  • Genetic and Molecular Epidemiology
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 0149-5992