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Olof Gidlöf

Research project participant

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MicroRNAs in the failing heart - Novel therapeutic targets?

Author

  • Olof Gidlöf
  • David Erlinge

Summary, in English

Abstract Heart failure is a common and disabling disease with high mortality that carries substantial societal costs. Current therapeutic strategies are aimed at relieving symptoms, avoiding hospitalization, and prolonging life, but disease progression is ultimately inevitable. MicroRNAs (miRNAs) are short, non-coding RNA molecules with pervasive roles in eukaryotic biology, annealing to complimentary sites on target mRNAs, and repressing gene expression. The fact that miRNAs are dysregulated in many human disorders, including cardiovascular disease, and the relative ease with which endogenous miRNA expression can be altered using synthetic antisense oligos has stirred enthusiasm for these molecules as potential drug targets. The aim of this review article was to summarize the current knowledge on the roles of miRNA in the pathophysiology of heart failure as well as the use of miRNAs as therapeutic targets and diagnostic tools for the disease.

Department/s

  • Cardiology

Publishing year

2014

Language

English

Pages

328-334

Publication/Series

Scandinavian Cardiovascular Journal

Volume

48

Issue

6

Document type

Journal article review

Publisher

Taylor & Francis

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

ISBN/ISSN/Other

  • ISSN: 1651-2006