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Olof Gidlöf

Research project participant

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Prasugrel 5 mg inhibits platelet P-selectin and GPIIb–IIIa expression in very elderly and non elderly : results from the GENERATIONS trial, a pharmacodynamic study in stable CAD patients

Author

  • Henrik Wagner
  • Christian Lood
  • Catharina Borna
  • Olof Gidlöf
  • Lennart Truedsson
  • Patricia Brown
  • Chunmei Zhou
  • Kenneth Winters
  • Joseph A. Jakubowski
  • David Erlinge

Summary, in English

Platelet P-selectin and activated glycoprotein IIb–IIIa (GPIIb–IIIa) are markers of platelet activation and mediates platelet aggregation. Prasugrel (Pras) 5 mg may be used in very elderly (VE) acute coronary syndrome (ACS) patients undergoing PCI, but its effect on platelet P-selectin and activated GPIIb–IIIa in those patients is not known. Stable ACS patients, VE (78 ± 5 years, n = 23) and non-elderly (NE) (55 ± 5 years, n = 22) were randomized to Pras (5 or 10 mg) or clopidogrel (Clop) 75 mg during three 12-day periods. Platelet activation markers were measured by flow cytometry on unstimulated or stimulated (adenosine diphosphate (ADP) 20 μM) platelets, before and after each dosing period.Results: At baseline there was no difference in platelet activation markers, either unstimulated or ADP-stimulated, between NE and VE. Pras 5 mg reduced both ADP-stimulated platelet P-selectin and activated GPIIb–IIIa in VE (p <0.01 for both analyses) and NE (p <0.001 and p <0.05, respectively). Clop 75 mg had a similar effect as Pras 5 mg but did not significantly reduce activated GPIIb–IIIa in VE. Prasugrel 10 mg resulted in decreased platelet activation in both age groups compared to Clop 75 mg (p <0.01).Conclusions: In VE and NE-patients, Pras 5 mg inhibited platelet P-selectin expression similar to Clop 75 mg and Pras 10 mg. Prasugrel 10 mg inhibited platelet P-selectin expression better than Clop 75 mg. Prasugrel 10 mg and 5 mg, but not Clop 75 mg, significantly inhibited activated GPIIb–IIIa in VE. This platelet reactivity data support the use of Pras 5 mg for VE patients.

Department/s

  • Cardiology
  • Rheumatology
  • Division of Microbiology, Immunology and Glycobiology - MIG

Publishing year

2016-10

Language

English

Pages

369-375

Publication/Series

Journal of Thrombosis and Thrombolysis

Volume

42

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Microbiology in the medical area

Keywords

  • Activated GPIIb–IIIa
  • Platelets
  • Prasugrel
  • Surface P-selectin

Status

Published

Project

  • Helsingborg Resuscitation and Cardiovascular Research Group

ISBN/ISSN/Other

  • ISSN: 0929-5305