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Olle Melander

Principal investigator

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Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

Author

  • Olga V Fedorova
  • Edward G Lakatta
  • Alexei Y Bagrov
  • Olle Melander

Summary, in English

Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Pages

534-541

Publication/Series

Journal of Hypertension

Volume

33

Issue

3

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1473-5598