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Olle Melander

Principal investigator

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Lp-PLA 2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease

Author

  • Shahab Fatemi
  • Anders Gottsäter
  • Moncef Zarrouk
  • Gunnar Engström
  • Olle Melander
  • Margaretha Persson
  • Stefan Acosta

Summary, in English


Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA
2
) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31
st
, 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA
2
activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA
2
mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA
2
activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease.

Department/s

  • Vascular Diseases - Clinical Research
  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Internal Medicine - Epidemiology

Publishing year

2019-04-04

Language

English

Publication/Series

Scientific Reports

Volume

9

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Vascular Diseases - Clinical Research
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 2045-2322