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Olle Melander

Principal investigator

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Diabetes Mellitus and Elevated Copeptin Levels in Middle Age Predict Low Cognitive Speed after Long-Term Follow-Up.

Author

  • Eva Tufvesson
  • Olle Melander
  • Lennart Minthon
  • Margaretha Persson
  • Peter Nilsson
  • Joachim Struck
  • Katarina Nägga

Summary, in English

Background/Aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT). Results: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance. Conclusion: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.

Department/s

  • Cardiovascular Research - Hypertension
  • Clinical Memory Research
  • Internal Medicine - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2013

Language

English

Pages

67-76

Publication/Series

Dementia and Geriatric Cognitive Disorders

Volume

35

Issue

1-2

Document type

Journal article

Publisher

Karger

Topic

  • Neurology

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Clinical Memory Research
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1420-8008