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Olle Melander

Principal investigator

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author

  • Elizabeth K. Speliotes
  • Cristen J. Willer
  • Sonja I. Berndt
  • Keri L. Monda
  • Gudmar Thorleifsson
  • Anne U. Jackson
  • Hana Lango Allen
  • Cecilia M. Lindgren
  • Jian'an Luan
  • Reedik Maegi
  • Joshua C. Randall
  • Sailaja Vedantam
  • Thomas W. Winkler
  • Lu Qi
  • Tsegaselassie Workalemahu
  • Iris M. Heid
  • Valgerdur Steinthorsdottir
  • Heather M. Stringham
  • Michael N. Weedon
  • Eleanor Wheeler
  • Andrew R. Wood
  • Teresa Ferreira
  • Robert J. Weyant
  • Ayellet V. Segre
  • Karol Estrada
  • Liming Liang
  • James Nemesh
  • Ju-Hyun Park
  • Stefan Gustafsson
  • Tuomas O. Kilpelaenen
  • Jian Yang
  • Nabila Bouatia-Naji
  • Tonu Esko
  • Mary F. Feitosa
  • Zoltan Kutalik
  • Massimo Mangino
  • Soumya Raychaudhuri
  • Andre Scherag
  • Albert Vernon Smith
  • Ryan Welch
  • Jing Hua Zhao
  • Katja K. Aben
  • Devin M. Absher
  • Najaf Amin
  • Anna L. Dixon
  • Eva Fisher
  • Nicole L. Glazer
  • Michael E. Goddard
  • Nancy L. Heard-Costa
  • Volker Hoesel
  • Jouke-Jan Hottenga
  • Asa Johansson
  • Toby Johnson
  • Shamika Ketkar
  • Claudia Lamina
  • Shengxu Li
  • Miriam F. Moffatt
  • Richard H. Myers
  • Narisu Narisu
  • John R. B. Perry
  • Marjolein J. Peters
  • Michael Preuss
  • Samuli Ripatti
  • Fernando Rivadeneira
  • Camilla Sandholt
  • Laura J. Scott
  • Nicholas J. Timpson
  • Jonathan P. Tyrer
  • Sophie van Wingerden
  • Richard M. Watanabe
  • Charles C. White
  • Fredrik Wiklund
  • Christina Barlassina
  • Daniel I. Chasman
  • Matthew N. Cooper
  • John-Olov Jansson
  • Robert W. Lawrence
  • Niina Pellikka
  • Inga Prokopenko
  • Jianxin Shi
  • Elisabeth Thiering
  • Helene Alavere
  • Maria T. S. Alibrandi
  • Peter Almgren
  • Alice M. Arnold
  • Thor Aspelund
  • Larry D. Atwood
  • Beverley Balkau
  • Anthony J. Balmforth
  • Amanda J. Bennett
  • Yoav Ben-Shlomo
  • Richard N. Bergman
  • Sven Bergmann
  • Heike Biebermann
  • Alexandra I. F. Blakemore
  • Tanja Boes
  • Lori L. Bonnycastle
  • Stefan R. Bornstein
  • Morris J. Brown
  • Thomas A. Buchanan
  • Fabio Busonero
  • Harry Campbell
  • Francesco P. Cappuccio
  • Christine Cavalcanti-Proenca
  • Yii-Der Ida Chen
  • Chih-Mei Chen
  • Peter S. Chines
  • Robert Clarke
  • Lachlan Coin
  • John Connell
  • Ian N. M. Day
  • Martin den Heijer
  • Jubao Duan
  • Shah Ebrahim
  • Paul Elliott
  • Roberto Elosua
  • Gudny Eiriksdottir
  • Michael R. Erdos
  • Johan G. Eriksson
  • Maurizio F. Facheris
  • Stephan B. Felix
  • Pamela Fischer-Posovszky
  • Aaron R. Folsom
  • Nele Friedrich
  • Nelson B. Freimer
  • Mao Fu
  • Stefan Gaget
  • Pablo V. Gejman
  • Eco J. C. Geus
  • Christian Gieger
  • Anette P. Gjesing
  • Anuj Goel
  • Philippe Goyette
  • Harald Grallert
  • Juergen Graessler
  • Danielle M. Greenawalt
  • Christopher J. Groves
  • Vilmundur Gudnason
  • Candace Guiducci
  • Anna-Liisa Hartikainen
  • Neelam Hassanali
  • Alistair S. Hall
  • Aki S. Havulinna
  • Caroline Hayward
  • Andrew C. Heath
  • Christian Hengstenberg
  • Andrew A. Hicks
  • Anke Hinney
  • Albert Hofman
  • Georg Homuth
  • Jennie Hui
  • Wilmar Igl
  • Carlos Iribarren
  • Bo Isomaa
  • Kevin B. Jacobs
  • Ivonne Jarick
  • Elizabeth Jewell
  • Ulrich John
  • Torben Jorgensen
  • Pekka Jousilahti
  • Antti Jula
  • Marika Kaakinen
  • Eero Kajantie
  • Lee M. Kaplan
  • Sekar Kathiresan
  • Johannes Kettunen
  • Leena Kinnunen
  • Joshua W. Knowles
  • Ivana Kolcic
  • Inke R. Koenig
  • Seppo Koskinen
  • Peter Kovacs
  • Johanna Kuusisto
  • Peter Kraft
  • Kirsti Kvaloy
  • Jaana Laitinen
  • Olivier Lantieri
  • Chiara Lanzani
  • Lenore J. Launer
  • Cecile Lecoeur
  • Terho Lehtimaeki
  • Guillaume Lettre
  • Jianjun Liu
  • Marja-Liisa Lokki
  • Mattias Lorentzon
  • Robert N. Luben
  • Barbara Ludwig
  • Paolo Manunta
  • Diana Marek
  • Michel Marre
  • Nicholas G. Martin
  • Wendy L. McArdle
  • Anne McCarthy
  • Barbara McKnight
  • Thomas Meitinger
  • Olle Melander
  • David Meyre
  • Kristian Midthjell
  • Grant W. Montgomery
  • Mario A. Morken
  • Andrew P. Morris
  • Rosanda Mulic
  • Julius S. Ngwa
  • Mari Nelis
  • Matt J. Neville
  • Dale R. Nyholt
  • Christopher J. O'Donnell
  • Stephen O'Rahilly
  • Ken K. Ong
  • Ben Oostra
  • Guillaume Pare
  • Alex N. Parker
  • Markus Perola
  • Irene Pichler
  • Kirsi H. Pietilaeinen
  • Carl G. P. Platou
  • Ozren Polasek
  • Anneli Pouta
  • Suzanne Rafelt
  • Olli Raitakari
  • Nigel W. Rayner
  • Martin Ridderstråle
  • Winfried Rief
  • Aimo Ruokonen
  • Neil R. Robertson
  • Peter Rzehak
  • Veikko Salomaa
  • Alan R. Sanders
  • Manjinder S. Sandhu
  • Serena Sanna
  • Jouko Saramies
  • Markku J. Savolainen
  • Susann Scherag
  • Sabine Schipf
  • Stefan Schreiber
  • Heribert Schunkert
  • Kaisa Silander
  • Juha Sinisalo
  • David S. Siscovick
  • Jan H. Smit
  • Nicole Soranzo
  • Ulla Sovio
  • Jonathan Stephens
  • Ida Surakka
  • Amy J. Swift
  • Mari-Liis Tammesoo
  • Jean-Claude Tardif
  • Maris Teder-Laving
  • Tanya M. Teslovich
  • John R. Thompson
  • Brian Thomson
  • Anke Toenjes
  • Tiinamaija Tuomi
  • Joyce B. J. van Meurs
  • Gert-Jan van Ommen
  • Vincent Vatin
  • Jorma Viikari
  • Sophie Visvikis-Siest
  • Veronique Vitart
  • Carla I. G. Vogel
  • Benjamin F. Voight
  • Lindsay L. Waite
  • Henri Wallaschofski
  • G. Bragi Walters
  • Elisabeth Widen
  • Susanna Wiegand
  • Sarah H. Wild
  • Gonneke Willemsen
  • Daniel R. Witte
  • Jacqueline C. Witteman
  • Jianfeng Xu
  • Qunyuan Zhang
  • Lina Zgaga
  • Andreas Ziegler
  • Paavo Zitting
  • John P. Beilby
  • I. Sadaf Farooqi
  • Johannes Hebebrand
  • Heikki V. Huikuri
  • Alan L. James
  • Mika Kaehoenen
  • Douglas F. Levinson
  • Fabio Macciardi
  • Markku S. Nieminen
  • Claes Ohlsson
  • Lyle J. Palmer
  • Paul M. Ridker
  • Michael Stumvoll
  • Jacques S. Beckmann
  • Heiner Boeing
  • Eric Boerwinkle
  • Dorret I. Boomsma
  • Mark J. Caulfield
  • Stephen J. Chanock
  • Francis S. Collins
  • L. Adrienne Cupples
  • George Davey Smith
  • Jeanette Erdmann
  • Philippe Froguel
  • Henrik Greonberg
  • Ulf Gyllensten
  • Per Hall
  • Torben Hansen
  • Tamara B. Harris
  • Andrew T. Hattersley
  • Richard B. Hayes
  • Joachim Heinrich
  • Frank B. Hu
  • Kristian Hveem
  • Thomas Illig
  • Marjo-Riitta Jarvelin
  • Jaakko Kaprio
  • Fredrik Karpe
  • Kay-Tee Khaw
  • Lambertus A. Kiemeney
  • Heiko Krude
  • Markku Laakso
  • Debbie A. Lawlor
  • Andres Metspalu
  • Patricia B. Munroe
  • Willem H. Ouwehand
  • Oluf Pedersen
  • Brenda W. Penninx
  • Annette Peters
  • Peter P. Pramstaller
  • Thomas Quertermous
  • Thomas Reinehr
  • Aila Rissanen
  • Igor Rudan
  • Nilesh J. Samani
  • Peter E. H. Schwarz
  • Alan R. Shuldiner
  • Timothy D. Spector
  • Jaakko Tuomilehto
  • Manuela Uda
  • Andre Uitterlinden
  • Timo T. Valle
  • Martin Wabitsch
  • Gerard Waeber
  • Nicholas J. Wareham
  • Hugh Watkins
  • James F. Wilson
  • Alan F. Wright
  • M. Carola Zillikens
  • Nilanjan Chatterjee
  • Steven A. McCarroll
  • Shaun Purcell
  • Eric E. Schadt
  • Peter M. Visscher
  • Themistocles L. Assimes
  • Ingrid B. Borecki
  • Panos Deloukas
  • Caroline S. Fox
  • Leif Groop
  • Talin Haritunians
  • David J. Hunter
  • Robert C. Kaplan
  • Karen L. Mohlke
  • Jeffrey R. O'Connell
  • Leena Peltonen
  • David Schlessinger
  • David P. Strachan
  • Cornelia M. van Duijn
  • H-Erich Wichmann
  • Timothy M. Frayling
  • Unnur Thorsteinsdottir
  • Goncalo R. Abecasis
  • Ines Barroso
  • Michael Boehnke
  • Kari Stefansson
  • Kari E. North
  • Mark I. McCarthy
  • Joel N. Hirschhorn
  • Erik Ingelsson
  • Ruth J. F. Loos

Summary, in English

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Hypertension
  • Diabetes - Clinical Obesity
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2010

Language

English

Pages

53-937

Publication/Series

Nature Genetics

Volume

42

Issue

11

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Hypertension
  • Diabetes - Clinical Obesity

ISBN/ISSN/Other

  • ISSN: 1546-1718