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Olle Melander

Principal investigator

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Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.

Author

  • Margrét Leosdottir
  • Ronnie Willenheimer
  • Christian Hall
  • Solve Tjora
  • Johan Malm
  • Olle Melander
  • Peter Nilsson

Summary, in English

Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among older subjects. Middle-aged men with new-onset and prevalent diabetes had higher Nt-proBNP than the reference group (FPG ≤5.0 mmol/L): 9.53 (p = 0.002) and 8.23 (p = 0.02) vs. 5.71 pmol/L. No differences in Nt-proBNP between categories of glucometabolic disturbance were observed among older men or women. Conclusions. The results indicate an age- and gender difference in the ability of Nt-proBNP to identify myocardial dysfunction in relation to glucometabolic disturbances. Therefore, Nt-proBNP should be used with caution as a general surrogate marker for myocardial dysfunction in this setting.

Department/s

  • Internal Medicine - Epidemiology
  • Cardiology Research Group
  • Clinical Chemistry, Malmö
  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

294-300

Publication/Series

Scandinavian cardiovascular journal : SCJ

Volume

45

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Cardiology Research Group
  • Clinical Chemistry, Malmö
  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1651-2006