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Olle Melander

Principal investigator

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hTERT T-1327/C polymorphism is not associated with age-related telomere attrition in peripheral blood

Author

  • Katarina Nordfjall
  • Pia Osterman
  • Olle Melander
  • Peter Nilsson
  • Goran Roos

Summary, in English

Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphisin was indicated 1327 bp upstream the hTERT transcription starting site. The C-1327/C genotype was associated with shorter telomere length compared to the alternative genotypes in healthy individuals and in coronary artery disease patients. We tested this observation and analysed telomere length and the T-1327/C polymorphism in 226 myocardial infarction patients and 444 controls from southern Sweden. No significant difference in telomere length was found among the genotypes after age adjustments in the control group (p = 0.794) or in the MI group (p = 0.339). Moreover, no increased age-related attrition was observed for the C-1327/C genotype as previously indicated, rather a telomere elongation in the control group (p = 0.021) not seen in the MI group (P = 0.249). (c) 2007 Elsevier Inc. All rights reserved.

Department/s

  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

Publishing year

2007

Language

English

Pages

215-218

Publication/Series

Biochemical and Biophysical Research Communications

Volume

358

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • polymorphism
  • telomere length
  • hTERT
  • age
  • myocardial infarction

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1090-2104