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Olle Melander

Principal investigator

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Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Author

  • Nina Geidenstam
  • Martin Magnusson
  • Anders P H Danielsson
  • Robert E Gerszten
  • Thomas J Wang
  • Lovisa E Reinius
  • Hindrik Mulder
  • Olle Melander
  • Martin Ridderstråle

Summary, in English

Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R(2) = 0.16-0.22, p < 0.002), whereas the scores increased in the <10% weight loss group (p < 0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.

Department/s

  • Diabetes - Clinical Obesity
  • Cardiovascular Research - Hypertension
  • Diabetes - Molecular Metabolism
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017

Language

English

Publication/Series

International Journal of Endocrinology

Volume

2017

Document type

Journal article

Publisher

Hindawi Limited

Topic

  • Nutrition and Dietetics

Keywords

  • Journal Article

Status

Published

Project

  • The use of Genomics and Proteomics for the Detection and Prevention of Cardiometabolic Disease

Research group

  • Diabetes - Clinical Obesity
  • Cardiovascular Research - Hypertension
  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 1687-8337