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Olle Melander

Principal investigator

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Lack of association between genetic variations in the KALRN region and ischemic stroke

Author

  • Sandra Olsson
  • Katarina Jood
  • Olle Melander
  • Marketa Sjögren
  • Bo Norrving
  • Michael Nilsson
  • Arne Lindgren
  • Christina Jern

Summary, in English

Objectives: To investigate whether KALRN gene variation is associated with ischemic stroke (IS). Design and methods: Associations to overall IS and IS subtypes were investigated in SAHLSIS, which comprises 844 patients with IS and 668 controls. Results: Associations between KALRN SNPs and overall IS and cardioembolic stroke were detected. Associations for overall IS were investigated in two additional Swedish samples, but could not be replicated. Conclusion: KALRN gene variation is not associated with overall IS. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Department/s

  • Cardiovascular Research - Hypertension
  • Neurology, Lund
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

1018-1020

Publication/Series

Clinical Biochemistry

Volume

44

Issue

12

Document type

Journal article

Publisher

Elsevier

Topic

  • Biochemistry and Molecular Biology

Keywords

  • Single nucleotide polymorphism
  • Genetics
  • Ischemic stroke
  • Kalirin
  • RhoGEF

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1873-2933