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Olle Melander

Principal investigator

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Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.

Author

  • Sara Halldén
  • Marketa Sjögren
  • Bo Hedblad
  • Gunnar Engström
  • Viktor Hamrefors
  • Jonas Manjer
  • Olle Melander

Summary, in English

Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.

Department/s

  • Cardiovascular Research - Hypertension
  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Epidemiology
  • Surgery
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016

Language

English

Pages

388-398

Publication/Series

Journal of Internal Medicine

Volume

279

Issue

4

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Epidemiology
  • Surgery

ISBN/ISSN/Other

  • ISSN: 1365-2796