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Olle Melander

Principal investigator

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Ceruloplasmin and atrial fibrillation: evidence of causality from a population-based Mendelian randomization study.

Author

  • Samuel Adamsson Eryd
  • Marketa Sjögren
  • Gustav Smith
  • Peter Nilsson
  • Olle Melander
  • Bo Hedblad
  • Gunnar Engström

Summary, in English

Inflammatory diseases and inflammatory markers secreted by the liver, including C-reactive protein (CRP) and ceruloplasmin, have been associated with incident atrial fibrillation (AF). Genetic studies have not supported a causal relationship between CRP and AF, but the relationship between ceruloplasmin and AF has not been studied. The purpose of this Mendelian randomization study was to explore whether genetic polymorphisms in the gene encoding ceruloplasmin are associated with elevated ceruloplasmin levels, and whether such genetic polymorphisms are also associated with the incidence of AF.

Department/s

  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Hypertension
  • Cardiology
  • Internal Medicine - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

164-171

Publication/Series

Journal of Internal Medicine

Volume

275

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1365-2796