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Olle Melander

Principal investigator

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Author

  • Evangelos Evangelou
  • Peter Almgren
  • Olle Melander
  • Paul Elliott
  • Mark J Caulfield

Summary, in English

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health

Publishing year

2018

Language

English

Pages

1412-1425

Publication/Series

Nature Genetics

Volume

50

Issue

10

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Medical Genetics
  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-1718