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Olle Melander

Principal investigator

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Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels

Author

  • Weiqiang Li
  • Mesude Bicak
  • Daniel D. Sjoberg
  • Emily Vertosick
  • Anders Dahlin
  • Olle Melander
  • David Ulmert
  • Hans Lilja
  • Robert J. Klein

Summary, in English

Background: Testing for prostate-specific antigen (PSA) levels in blood are widely used and associated with prostate cancer risk and outcome. After puberty, PSA levels increase by age and multiple single nucleotide polymorphisms (SNPs) have been found to be associated with PSA levels. However, the relationship between the effects of SNPs and age on PSA remains unknown. Methods: To test for SNP × age interaction, we conducted a genome-wide association study using 2394 men without prostate cancer diagnosis from Malmö, Sweden as a discovery set and 2137 men from the eMERGE study (USA) for validation. Linear regression was used to identify significant interactions between SNP and age (p < 1 × 10−4 for discovery, p <.05 for validation). Results: The 15 SNPs from three different loci (8p11.22, 8p12, 3q25.31) are found to have age-specific effect on PSA levels. Expression quantitative trait loci (eQTLs) analysis shows that 12 SNPs from 3q25.31 locus affect the expression level of three genes: KCNAB1, SLC33A1, PLCH1. Conclusions: Our results suggest that SNPs may have age-specific effect on PSA levels, which provides new direction to study genetic markers for PSA.

Department/s

  • Internal Medicine - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • LUCC - Lund University Cancer Centre
  • Clinical Chemistry, Malmö

Publishing year

2020-12-01

Language

English

Pages

1405-1412

Publication/Series

Prostate

Volume

80

Issue

16

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cancer and Oncology

Keywords

  • eQTL
  • GWAS
  • prostate cancer
  • PSA
  • SNPs

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 0270-4137