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Olle Melander

Principal investigator

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Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.

Author

  • Ming-Mei Shang
  • Husain A Talukdar
  • Jennifer J Hofmann
  • Colin Niaudet
  • Hassan Foroughi Asl
  • Rajeev K Jain
  • Aranzazu Rossignoli
  • Cecilia Cedergren
  • Angela Silveira
  • Bruna Gigante
  • Karin Leander
  • Ulf de Faire
  • Anders Hamsten
  • Arno Ruusalepp
  • Olle Melander
  • Torbjörn Ivert
  • Tom Michoel
  • Eric E Schadt
  • Christer Betsholtz
  • Josefin Skogsberg
  • Johan L M Björkegren

Summary, in English

Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

2068-2077

Publication/Series

Arteriosclerosis, Thrombosis and Vascular Biology

Volume

34

Issue

9

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1524-4636