Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Olle Melander

Principal investigator

Default user image.

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene.

Author

  • Håkan Lövkvist
  • Sandra Olsson
  • Peter Höglund
  • Olle Melander
  • Christina Jern
  • Marketa Sjögren
  • Gunnar Engström
  • Gustav Smith
  • Bo Hedblad
  • Gunnar Andsberg
  • Hossein Delavaran
  • Katarina Jood
  • Ulf Kristoffersson
  • Holger Luthman
  • Bo Norrving
  • Arne Lindgren

Summary, in English

Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been studied in this context. We performed a multi-centre study involving a large sample of 2599 IS patients and 2093 control subjects from the south and west regions of Sweden to replicate previous studies regarding IS risk and rs12188950. Subjects from Lund Stroke Register (LSR), Malmö Diet and Cancer Study (MDC) and Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) were enroled. Subgroups of participants with hypertension and participants <55 years of age, as well as the TOAST subgroups large vessel disease, small vessel disease and cardioembolism, were also assessed. Univariate odds ratios (ORs) and ORs controlling for hypertension, diabetes and current smoking were calculated. We additionally performed a meta-analysis including 10 500 patients and 10 102 control subjects from 17 publications (including the present study). When assessing pooled data from LSR, MDC and SAHLSIS we obtained no association between IS and rs12188950 for all participants (OR=0.93; 95% confidence interval (CI): 0.83-1.05). Significant associations were not found for hypertensive participants or participants with age <55, or when separately evaluating patients from the three different TOAST subgroups. The meta-analysis showed no significant overall estimate (OR=0.96; 95% CI: 0.89-1.04) with significant heterogeneity for random effect (P=0.042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either.European Journal of Human Genetics advance online publication, 25 January 2012; doi:10.1038/ejhg.2012.4.

Department/s

  • Neurology, Lund
  • Vessel Wall Biology
  • Division of Clinical Chemistry and Pharmacology
  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Epidemiology
  • Division of Clinical Genetics
  • Genetics
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

783-789

Publication/Series

European Journal of Human Genetics

Volume

20

Issue

7

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Medical Genetics

Status

Published

Research group

  • Vessel Wall Biology
  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Epidemiology
  • Genetics

ISBN/ISSN/Other

  • ISSN: 1476-5438