Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Olle Melander

Principal investigator

Default user image.

Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Author

  • Katarzyna Polonis
  • Renata Wawrzyniak
  • Emilia Daghir-Wojtkowiak
  • Anna Szyndler
  • Marzena Chrostowska
  • Olle Melander
  • Michał Hoffmann
  • Marta Kordalewska
  • Joanna Raczak-Gutknecht
  • Ewa Bartosińska
  • Roman Kaliszan
  • Krzysztof Narkiewicz
  • Michał J. Markuszewski

Summary, in English

Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolomic approach was used to identify plasma metabolites in an age-, BMI-, and sex-matched groups of EVA (n = 79) and non-EVA (n = 73) individuals with hypertension. After raw data processing and filtration, 497 putative compounds were characterized, out of which 4 were identified as lysophosphaditylcholines (LPCs) [LPC (18:2), LPC (16:0), LPC (18:0), and LPC (18:1)]. A main finding of this study shows that identified LPCs were independently associated with EVA status. Although LPCs have been shown previously to be positively associated with inflammation and atherosclerosis, we observed that hypertensive individuals characterized by 4 down-regulated LPCs had 3.8 times higher risk of EVA compared to those with higher LPC levels (OR = 3.8, 95% CI 1.7–8.5, P < 0.001). Our results provide new insights into a metabolomic phenotype of vascular aging and warrants further investigation of negative association of LPCs with EVA status. This study suggests that LPCs are potential candidates to be considered for further evaluation and validation as predictors of EVA in patients with hypertension.

Department/s

  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2020-02-07

Language

English

Publication/Series

Frontiers in Molecular Biosciences

Volume

7

Document type

Journal article

Publisher

Frontiers Media S. A.

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • arterial stiffness
  • early vascular aging
  • metabolomics
  • phospholipid metabolism
  • pulse wave velocity

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 2296-889X