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Olle Melander

Principal investigator

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Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension


  • Katarzyna Polonis
  • Renata Wawrzyniak
  • Emilia Daghir-Wojtkowiak
  • Anna Szyndler
  • Marzena Chrostowska
  • Olle Melander
  • Michał Hoffmann
  • Marta Kordalewska
  • Joanna Raczak-Gutknecht
  • Ewa Bartosińska
  • Roman Kaliszan
  • Krzysztof Narkiewicz
  • Michał J. Markuszewski

Summary, in English

Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolomic approach was used to identify plasma metabolites in an age-, BMI-, and sex-matched groups of EVA (n = 79) and non-EVA (n = 73) individuals with hypertension. After raw data processing and filtration, 497 putative compounds were characterized, out of which 4 were identified as lysophosphaditylcholines (LPCs) [LPC (18:2), LPC (16:0), LPC (18:0), and LPC (18:1)]. A main finding of this study shows that identified LPCs were independently associated with EVA status. Although LPCs have been shown previously to be positively associated with inflammation and atherosclerosis, we observed that hypertensive individuals characterized by 4 down-regulated LPCs had 3.8 times higher risk of EVA compared to those with higher LPC levels (OR = 3.8, 95% CI 1.7–8.5, P < 0.001). Our results provide new insights into a metabolomic phenotype of vascular aging and warrants further investigation of negative association of LPCs with EVA status. This study suggests that LPCs are potential candidates to be considered for further evaluation and validation as predictors of EVA in patients with hypertension.


  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year





Frontiers in Molecular Biosciences



Document type

Journal article


Frontiers Media S. A.


  • Cardiac and Cardiovascular Systems


  • arterial stiffness
  • early vascular aging
  • metabolomics
  • phospholipid metabolism
  • pulse wave velocity



Research group

  • Cardiovascular Research - Hypertension


  • ISSN: 2296-889X