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Olle Melander

Principal investigator

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Metabolite profiles and the risk of developing diabetes

Author

  • Thomas J. Wang
  • Martin G. Larson
  • Ramachandran S. Vasan
  • Susan Cheng
  • Eugene P. Rhee
  • Elizabeth McCabe
  • Gregory D. Lewis
  • Caroline S. Fox
  • Paul F. Jacques
  • Celine Fernandez
  • Christopher J. O'Donnell
  • Stephen A. Carr
  • Vamsi K. Mootha
  • Jose C. Florez
  • Amanda Souza
  • Olle Melander
  • Clary B. Clish
  • Robert E. Gerszten

Summary, in English

Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes. Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes. Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tandem mass spectrometry (LC-MS). Cases and controls were matched for age, body mass index and fasting glucose. Five branched-chain and aromatic amino acids had highly significant associations with future diabetes: isoleucine, leucine, valine, tyrosine and phenylalanine. A combination of three amino acids predicted future diabetes (with a more than fivefold higher risk for individuals in top quartile). The results were replicated in an independent, prospective cohort. These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

83-448

Publication/Series

Nature Medicine

Volume

17

Issue

4

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-170X