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Olle Melander

Principal investigator

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Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies

Author

  • Sandra Olsson
  • Olle Melander
  • Katarina Jood
  • Gustav Smith
  • Håkan Lövkvist
  • Marketa Sjögren
  • Gunnar Engström
  • Bo Norrving
  • Arne Lindgren
  • Christina Jern

Summary, in English

Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)

Department/s

  • Cardiovascular Research - Hypertension
  • Neurology, Lund
  • Cardiovascular Research - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

214-216

Publication/Series

Stroke: a journal of cerebral circulation

Volume

42

Issue

1

Document type

Journal article

Publisher

American Heart Association

Topic

  • Neurology

Keywords

  • stroke
  • single-nucleotide polymorphism
  • genetic association studies

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1524-4628