Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Olle Melander

Principal investigator

Default user image.

Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Author

  • Weiqiang Li
  • Mridu Middha
  • Mesude Bicak
  • Daniel D. Sjoberg
  • Emily Vertosick
  • Anders Dahlin
  • Christel Häggström
  • Göran Hallmans
  • Ann Charlotte Rönn
  • Pär Stattin
  • Olle Melander
  • David Ulmert
  • Hans Lilja
  • Robert J. Klein

Summary, in English

We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

Department/s

  • Internal Medicine - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Clinical Chemistry, Malmö

Publishing year

2018-01-01

Language

English

Pages

710-719

Publication/Series

European Urology

Volume

74

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Medical Genetics
  • Cancer and Oncology

Keywords

  • AOX1
  • Expression quantitative trait locus
  • Genome-wide association study
  • Prostate cancer
  • Survival analysis

Status

Published

Research group

  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 0302-2838