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Olle Melander

Principal investigator

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Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort

Author

  • Marion Carayol
  • Michael F. Leitzmann
  • Pietro Ferrari
  • Raul Zamora-Ros
  • David Achaintre
  • Magdalena Stepien
  • Julie A Schmidt
  • Ruth C Travis
  • Kim Overvad
  • Anne Tjønneland
  • Louise Hansen
  • Rudolf Kaaks
  • Tilman Kühn
  • Heiner Boeing
  • Ursula Bachlechner
  • Antonia Trichopoulou
  • Christina Bamia
  • Domenico Palli
  • Claudia Agnoli
  • Rosario Tumino
  • Paolo Vineis
  • Salvatore Panico
  • J Ramón Quirós
  • Emilio Sánchez-Cantalejo
  • José María Huerta
  • Eva Ardanaz
  • Larraitz Arriola
  • Antonio Agudo
  • Jan Nilsson
  • Olle Melander
  • Bas Bueno de Mesquita
  • Petra H. Peeters
  • Nick Wareham
  • Kay-Tee Khaw
  • Mazda Jenab
  • Timothy J Key
  • Augustin Scalbert
  • Sabina Rinaldi

Summary, in English

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.

Department/s

  • Department of Clinical Sciences, Malmö
  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017-09-01

Language

English

Pages

3137-3146

Publication/Series

Journal of Proteome Research

Volume

16

Issue

9

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • blood
  • body mass index
  • metabolic profiling
  • obesity
  • targeted metabolome

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1535-3893