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Olle Melander

Principal investigator

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Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Author

  • Olle Melander
  • Marju Orho-Melander
  • Jonas Manjer
  • Thomas Svensson
  • Peter Almgren
  • Peter Nilsson
  • Gunnar Engström
  • Bo Hedblad
  • Signe Borgquist
  • Oliver Hartmann
  • Joachim Struck
  • Andreas Bergmann
  • Mattias Belting

Summary, in English

In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.

Department/s

  • Tumor microenvironment
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Hypertension
  • Diabetes - Cardiovascular Disease
  • Surgery
  • Genomics, Diabetes and Endocrinology
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Epidemiology
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Breastcancer-genetics
  • Tumor microenvironment

Publishing year

2015

Language

English

Pages

81-2632

Publication/Series

Journal of Clinical Oncology

Volume

33

Issue

24

Document type

Journal article

Publisher

American Society of Clinical Oncology

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Tumor microenvironment
  • Cardiovascular Research - Hypertension
  • Diabetes - Cardiovascular Disease
  • Surgery
  • Genomics, Diabetes and Endocrinology
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1527-7755