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Olle Melander

Principal investigator

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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Author

  • Aida Ferreiro-Iglesias
  • Corina Lesseur
  • James McKay
  • Rayjean J. Hung
  • Younghun Han
  • Xuchen Zong
  • David Christiani
  • Mattias Johansson
  • Xiangjun Xiao
  • Yafang Li
  • David C. Qian
  • Xuemei Ji
  • Geoffrey Liu
  • Neil Caporaso
  • Ghislaine Scelo
  • David Zaridze
  • Anush Mukeriya
  • Milica Kontic
  • Simona Ognjanovic
  • Jolanta Lissowska
  • Małgorzata Szołkowska
  • Beata Swiatkowska
  • Vladimir Janout
  • Ivana Holcatova
  • Ciprian Bolca
  • Milan Savic
  • Miodrag Ognjanovic
  • Stig Egil Bojesen
  • Xifeng Wu
  • Demetrios Albanes
  • Melinda C. Aldrich
  • Adonina Tardon
  • Ana Fernandez-Somoano
  • Guillermo Fernandez-Tardon
  • Loic Le Marchand
  • Gadi Rennert
  • Chu Chen
  • Jennifer Doherty
  • Gary Goodman
  • Heike Bickeböller
  • H. Erich Wichmann
  • Angela Risch
  • Albert Rosenberger
  • Hongbing Shen
  • Juncheng Dai
  • John K. Field
  • Michael Davies
  • Penella Woll
  • M. Dawn Teare
  • Lambertus A. Kiemeney
  • Erik H.F.M. van der Heijden
  • Jian Min Yuan
  • Yun Chul Hong
  • Aage Haugen
  • Shanbeh Zienolddiny
  • Stephen Lam
  • Ming Sound Tsao
  • Mikael Johansson
  • Kjell Grankvist
  • Matthew B. Schabath
  • Angeline Andrew
  • Eric Duell
  • Olle Melander
  • Hans Brunnström
  • Philip Lazarus
  • Susanne Arnold
  • Stacey Slone
  • Jinyoung Byun
  • Ahsan Kamal
  • Dakai Zhu
  • Maria Teresa Landi
  • Christopher I. Amos
  • Paul Brennan

Summary, in English

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA–tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Improved diagnostics and prognostics of lung cancer and metastases to the lungs
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2018

Language

English

Publication/Series

Nature Communications

Volume

9

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Improved diagnostics and prognostics of lung cancer and metastases to the lungs

ISBN/ISSN/Other

  • ISSN: 2041-1723