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Olle Melander

Principal investigator

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Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients

Author

  • Martin Magnusson
  • Stefan Jovinge
  • Kambiz Shahgaldi
  • Bo Israelsson
  • Leif Groop
  • Olle Melander

Summary, in English

Background: The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients. Methods: Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP and AER in 153 consecutive asymptomatic patients with type 2 diabetes. Results: LVSD was present in 6.1% of patients whereas 49% (29% mild, 19% moderate and 0.7% severe) had LVDD and 9.4% had left ventricular hypertrophy. Increasing age (P < 0.0001) was the only independent variable related to mild LVDD whereas increasing BNP (P = 0.01), systolic blood pressure (P = 0.01), age (P = 0.003) and female gender (P = 0.04) were independent determinants of moderate to severe LVDD. AER (P = 0.003), age (P = 0.01) and male gender (P = 0.006) were directly and independently related to LVM. Conclusion: About half of asymptomatic type 2 diabetes patients have LVDD. Of those, more than one third display moderate LVDD pattern paralleled by increases in BNP, suggesting markedly increased risk of heart failure, especially in females, whereas AER and male sex are related to LVM.

Department/s

  • Cardiovascular Research - Hypertension
  • Stem Cell Center
  • Department of Clinical Sciences, Malmö
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2010

Language

English

Publication/Series

Cardiovascular Diabetology

Volume

9

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Cardiac and Cardiovascular Systems
  • Cell and Molecular Biology
  • Clinical Medicine
  • Endocrinology and Diabetes

Status

Published

Project

  • Kompetens centrum Hjärta och Diabetes - KHD

Research group

  • Cardiovascular Research - Hypertension
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1475-2840