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Olle Melander

Principal investigator

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Exploration of pathophysiological pathways for incident atrial fibrillation using a multiplex proteomic chip

Author

  • John Molvin
  • Amra Jujic
  • Olle Melander
  • Manan Pareek
  • Lennart Råstam
  • Ulf Lindblad
  • Bledar Daka
  • Margret Leosdottir
  • Peter Nilsson
  • Michael Olsen
  • Martin Magnusson

Summary, in English

Objective Atrial fibrillation (AF) is the most common arrhythmia and associated with increased morbidity and mortality. Its increasing prevalence calls for novel biomarkers to identify underlying pathophysiological mechanisms as well as patients at risk. Methods Plasma samples from 1694 individuals from the Swedish population-based Malmö Preventive Project (mean age 69.5 years; 29.3% female; mean follow-up time 9.7±3.1 years) were analysed with the Olink proximity extension assay CVD III panel consisting of 92 proteins to identify proteins associated with incident AF or atrial flutter, referred to as incident AF. Incident cases of AF (n=278) were retrieved by linkage to the registers. Participants were followed until the first episode of AF or until censoring by death or emigration. Bonferroni-corrected multivariable Cox regression models adjusted for known risk factors were used to explore possible associations of the 92 proteins and incidence of AF. Results Multivariable Cox regression analyses of 11 proteins associated with incident AF (mean follow-up time 9.7±3.1 years) after Bonferroni correction confirmed N-terminal pro-B-type natriuretic peptide (HR per 1 SD increment (95% CI) 1.80 (1.58 to 2.04); p=1.2×10 -19) as risk marker of incident AF. Further, matrix metalloproteinase-2 (1.22 (1.07 to 1.39); p=0.002) and osteopontin (1.27 (1.12 to 1.44); p=2.7×10 -4) were associated with incident AF at follow-up independently of traditional risk markers and NT-proBNP. Conclusion In a general Swedish population, we confirmed the well-known association of NT-proBNP with incident AF and also identified matrix metalloproteinase-2 and osteopontin as novel risk markers for incident AF, independently of traditional risk factors and NT-proBNP.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Department of Clinical Sciences, Malmö
  • Family Medicine and Community Medicine
  • Internal Medicine - Epidemiology
  • WCMM-Wallenberg Centre for Molecular Medicine

Publishing year

2020-03-15

Language

English

Publication/Series

Open Heart

Volume

7

Issue

1

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • atrial fibrillation
  • matrix metalloproteinase-2
  • NT-proBNP
  • osteopontin

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Family Medicine and Community Medicine
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 2398-595X