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Olle Melander

Principal investigator

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History of syncope predicts loss of consciousness after head trauma: Retrospective study


  • Dorota Zysko
  • Richard Sutton
  • Dariusz Timler
  • Stanislaw Furtan
  • Olle Melander
  • Artur Fedorowski

Summary, in English

Background: Head trauma may present as transient loss of consciousness (TLOC) currently classified as traumatic in origin, in contrast to non-traumatic forms, such as syncope. Whether past history of syncope predisposes to loss of consciousness after head injury has been poorly studied. Methods: A retrospective analysis of data obtained from 818 consecutive patients admitted to Emergency Departments was conducted. Face-to-face semi-structured interviews were performed, where patients' past history of syncope and head injury were explored. Head injury events were stratified as high-or low-energy trauma. Data regarding past syncopal events were explored in regard to number, age at the first occurrence, and syncope circumstances. Multivariate logistic regression model was applied to assess the relationship between loss of consciousness during head injury and past history of syncope. Results: Both past history of non-traumatic TLOC (odds ratio [OR] 3.78; 95% confidence interval [CI] 2.13-6.68, p < 0.001) and high-energy mechanism (OR 3.84; 95% CI 2.35-6.28, p < 0.001) predicted TLOC after head trauma. This relationship was even stronger when past episodes of TLOC were limited to those typical for reflex syncope (OR 4.34; 95% CI 2.34-7.89, p < 0.001). Further, the number of non-traumatic TLOC episodes in the patient's history was also predictive of TLOC after head injury (OR per 1 episode: 1.24; 95% CI 1.04-1.48, p = 0.015). Conclusions: Syncope in a patient's history predicts loss of consciousness after head injury. The clinical importance of this finding merits further investigation.


  • Cardiovascular Research - Hypertension
  • EpiHealth: Epidemiology for Health

Publishing year







Cardiology Journal





Document type

Journal article


Via Medica


  • Cardiac and Cardiovascular Systems


  • head trauma
  • emergency department
  • loss of consciousness
  • syncope
  • vasovagal syncope



Research group

  • Cardiovascular Research - Hypertension


  • ISSN: 1898-018X