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Olle Melander

Principal investigator

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Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant.

Author

  • Freya Boardman-Pretty
  • Andrew J P Smith
  • Jackie Cooper
  • Jutta Palmen
  • Lasse Folkersen
  • Anders Hamsten
  • Alberico L Catapano
  • Olle Melander
  • Jacqueline F Price
  • Meena Kumari
  • John E Deanfield
  • Mika Kivimäki
  • Karl Gertow
  • Andrea Baragetti
  • Giuseppe Danilo Norata
  • Steve E Humphries

Summary, in English

-Carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis that can predict cardiovascular disease (CVD) events over traditional risk factors. This study examined the BCAR1-CFDP1-TMEM170A locus on chromosome 16, associated with cIMT and coronary artery disease in the IMPROVE cohort, to identify the functional variant.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Pages

696-706

Publication/Series

Circulation: Cardiovascular Genetics

Volume

8

Issue

5

Document type

Journal article

Publisher

American Heart Association

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1942-325X