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Olle Melander

Principal investigator

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Germline genetics of cancer of unknown primary (CUP) and its specific subtypes.

Author

  • Kari Hemminki
  • Bowang Chen
  • Abhishek Kumar
  • Olle Melander
  • Jonas Manjer
  • Göran Hallmans
  • Ulrika Pettersson-Kymmer
  • Claes Ohlsson
  • Gunnar Folprecht
  • Harald Löffler
  • Alwin Krämer
  • Asta Försti

Summary, in English

Cancer of unknown primary site (CUP) is a fatal cancer diagnosed through metastases at various organs. Little is known about germline genetics of CUP which appears worth of a search in view of reported familial associations in CUP. In the present study, samples from CUP patients were identified from 2 Swedish biobanks and a German clinical trial, totaling 578 CUP patients and 7628 regionally matched controls. Diagnostic data specified the organ where metastases were diagnosed. We carried out a genome-wide association study on CUP cases and controls. In the whole sample set, 6 loci reached an allelic p-value in the range of 10-7 and were supported by data from the three centers. Three associations were located next to non-coding RNA genes. rs2660852 flanked 5'UTR of LTA4H (leukotriene A4 hydrolase), rs477145 was intronic to TIAM1 (T-cell lymphoma invasion and metastases) and rs2835931 was intronic to KCNJ6 (potassium channel, inwardly rectifying subfamily J, member 6). In analysis of subgroups of CUP patients (smokers, non-smokers and CUP with liver metastases) genome-wide significant associations were noted. For patients with liver metastases associations on chromosome 6 and 11, the latter including a cluster of genes DHCR7 and NADSYN1, encoding key enzymes in cholesterol and NAD synthesis, and KRTAP5-7, encoding a keratin associated protein. This first GWAS on CUP provide preliminary evidence that germline genes relating to inflammation (LTA4H), metastatic promotion (TIAM1) in association with lipid metabolic disturbance (chromosome 11 cluster) may contribute to the risk of CUP.

Department/s

  • Family Medicine and Clinical Epidemiology
  • Department of Clinical Sciences, Malmö
  • Surgery
  • EpiHealth: Epidemiology for Health

Publishing year

2016-03-03

Language

English

Pages

22140-22149

Publication/Series

Oncotarget

Volume

7

Issue

16

Document type

Journal article

Publisher

Impact Journals, LLC

Topic

  • Cancer and Oncology
  • Medical Genetics

Status

Published

Research group

  • Family Medicine and Clinical Epidemiology
  • Surgery

ISBN/ISSN/Other

  • ISSN: 1949-2553