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Olle Melander

Principal investigator

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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Author

  • Jeanette Erdmann
  • Anika Grosshennig
  • Peter S. Braund
  • Inke R. Koenig
  • Christian Hengstenberg
  • Alistair S. Hall
  • Patrick Linsel-Nitschke
  • Sekar Kathiresan
  • Ben Wright
  • David-Alexandre Tregouet
  • Francois Cambien
  • Petra Bruse
  • Zouhair Aherrahrou
  • Arnika K. Wagner
  • Klaus Stark
  • Stephen M. Schwartz
  • Veikko Salomaa
  • Roberto Elosua
  • Olle Melander
  • Benjamin F. Voight
  • Christopher J. O'Donnell
  • Leena Peltonen
  • David S. Siscovick
  • David Altshuler
  • Piera Angelica Merlini
  • Flora Peyvandi
  • Luisa Bernardinelli
  • Diego Ardissino
  • Arne Schillert
  • Stefan Blankenberg
  • Tanja Zeller
  • Philipp Wild
  • Daniel F. Schwarz
  • Laurence Tiret
  • Claire Perret
  • Stefan Schreiber
  • Nour Eddine El Mokhtari
  • Arne Schaefer
  • Winfried Maerz
  • Wilfried Renner
  • Peter Bugert
  • Harald Klueter
  • Juergen Schrezenmeir
  • Diana Rubin
  • Stephen G. Ball
  • Anthony J. Balmforth
  • H-Erich Wichmann
  • Thomas Meitinger
  • Marcus Fischer
  • Christa Meisinger
  • Jens Baumert
  • Annette Peters
  • Willem H. Ouwehand
  • Panos Deloukas
  • John R. Thompson
  • Andreas Ziegler
  • Nilesh J. Samani
  • Heribert Schunkert

Summary, in English

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

Department/s

  • Cardiovascular Research - Hypertension

Publishing year

2009

Language

English

Pages

280-282

Publication/Series

Nature Genetics

Volume

41

Issue

3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-1718