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Olle Melander

Principal investigator

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Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension

Author

  • Olle Melander
  • E Frandsen
  • Leif Groop
  • Lennart Hulthén

Summary, in English

The aim of the present Study was to investigate whether plasma concentration of proANP(1-30), the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of Salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP(1-30) and urinary urodilatin excretion were determined at baseline, after I week on a low-salt diet (10 nmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy, subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased proANP(1-30) (668+/-330 versus 358+/-150 pmol/L P<0.00001) and urodilatin (18.7+/-5.2 versus 16.0+/-8.3 pmol/24 h P<0.05). ProANP(1-30) correlated with salt sensitivity at baseline (r=0.76, P<0.000001). after the low- (r=0.80. P<0.0000001) and high-salt diets (r=0.85, P<0.00000001). The increase proANP(1-30) induced by changing from the low- to the high-salt diet was also directly related to salt sensitivity (r=0.78, P<0.000001). ProANP(1-30) was not related to urinary sodium excretion. Neither urodilatin nor the sodium-induced change in urodilatin correlated with salt sensitivity. However, urodilatin was related to the urinary sodium excretion at baseline (r=0.58, P<0.01) and after the high-salt diet (r=0.62, P<0.001). In conclusion, the close correlations between proANP(1-30) and salt sensitivity suggest that proANP(1-30) may serve as a marker for salt sensitivity and could be useful in identifying subjects who would benefit from dietary salt restriction to prevent development of hypertension.

Department/s

  • Department of Clinical Sciences, Malmö
  • Genomics, Diabetes and Endocrinology

Publishing year

2002

Language

English

Pages

996-999

Publication/Series

Hypertension

Volume

39

Issue

5

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • sodium
  • dietary
  • natriuretic peptides
  • essential
  • hypertension
  • genetics
  • blood pressure

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1524-4563