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Olle Melander

Principal investigator

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Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.

Author

  • Hayato Tada
  • Hong-Hee Won
  • Olle Melander
  • Jian Yang
  • Gina M Peloso
  • Sekar Kathiresan

Summary, in English

-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

583-587

Publication/Series

Circulation: Cardiovascular Genetics

Volume

7

Issue

5

Document type

Journal article

Publisher

American Heart Association

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1942-325X