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Olle Melander

Principal investigator

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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Author

  • Nicole Soranzo
  • Tim D. Spector
  • Massimo Mangino
  • Brigitte Kuehnel
  • Augusto Rendon
  • Alexander Teumer
  • Christina Willenborg
  • Benjamin Wright
  • Li Chen
  • Mingyao Li
  • Perttu Salo
  • Benjamin F. Voight
  • Philippa Burns
  • Roman A. Laskowski
  • Yali Xue
  • Stephan Menzel
  • David Altshuler
  • John R. Bradley
  • Suzannah Bumpstead
  • Mary-Susan Burnett
  • Joseph Devaney
  • Angela Doering
  • Roberto Elosua
  • Stephen E. Epstein
  • Wendy Erber
  • Mario Falchi
  • Stephen F. Garner
  • Mohammed J. R. Ghori
  • Alison H. Goodall
  • Rhian Gwilliam
  • Hakon H. Hakonarson
  • Alistair S. Hall
  • Naomi Hammond
  • Christian Hengstenberg
  • Thomas Illig
  • Inke R. Koenig
  • Christopher W. Knouff
  • Ruth McPherson
  • Olle Melander
  • Vincent Mooser
  • Matthias Nauck
  • Markku S. Nieminen
  • Christopher J. O'Donnell
  • Leena Peltonen
  • Simon C. Potter
  • Holger Prokisch
  • Daniel J. Rader
  • Catherine M. Rice
  • Robert Roberts
  • Veikko Salomaa
  • Jennifer Sambrook
  • Stefan Schreiber
  • Heribert Schunkert
  • Stephen M. Schwartz
  • Jovana Serbanovic-Canic
  • Juha Sinisalo
  • David S. Siscovick
  • Klaus Stark
  • Ida Surakka
  • Jonathan Stephens
  • John R. Thompson
  • Uwe Voelker
  • Henry Voelzke
  • Nicholas A. Watkins
  • George A. Wells
  • H-Erich Wichmann
  • David A. Van Heel
  • Chris Tyler-Smith
  • Swee Lay Thein
  • Sekar Kathiresan
  • Markus Perola
  • Muredach P. Reilly
  • Alexandre F. R. Stewart
  • Jeanette Erdmann
  • Nilesh J. Samani
  • Christa Meisinger
  • Andreas Greinacher
  • Panos Deloukas
  • Willem H. Ouwehand
  • Christian Gieger

Summary, in English

The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.

Department/s

  • Cardiovascular Research - Hypertension

Publishing year

2009

Language

English

Pages

38-1182

Publication/Series

Nature Genetics

Volume

41

Issue

11

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1546-1718