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Olle Melander

Principal investigator

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Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project

Author

  • Kristina Bengtsson Boström
  • Marju Orho-Melander
  • Ulf Lindblad
  • Olle Melander
  • Erik Bøg-Hansen
  • Jonas Ranstam
  • Lennart Råstam
  • Leif Groop

Summary, in English

OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so when patients with type 2 diabetes were excluded from the analysis (OR = 1.45, CI = 1.01-2.09). The strongest association was with the combination of type 2 diabetes and hypertension (OR = 2.19, CI = 1.09-4.38). There was no association with type 2 diabetes without hypertension. No association was observed between the M235T variant or the 3'-microsatellite polymorphism of the AGT gene and hypertension. CONCLUSION: The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly when associated with type 2 diabetes. No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.

Department/s

  • Genomics, Diabetes and Endocrinology
  • Community Medicine
  • Cardiovascular Research - Hypertension
  • Department of Clinical Sciences, Malmö
  • Orthopaedics (Lund)

Publishing year

1999

Language

English

Pages

1569-1575

Publication/Series

Journal of Hypertension

Volume

17

Issue

11

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Hypertension
  • Diabetes mellitus
  • Polymorphism
  • Peptidyl-dipeptidase A
  • Gene
  • Angiotensinogen
  • Genetic determinism
  • Human
  • Peptidyl-dipeptidases
  • Peptidases
  • Hydrolases
  • Enzyme
  • Cardiovascular disease
  • Endocrinopathy

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology
  • Community Medicine
  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 1473-5598