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Olle Melander

Principal investigator

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Distinct metabolomic signatures are associated with longevity in humans.

Author

  • Susan Cheng
  • Martin G Larson
  • Elizabeth L McCabe
  • Joanne M Murabito
  • Eugene P Rhee
  • Jennifer E Ho
  • Paul F Jacques
  • Anahita Ghorbani
  • Martin Magnusson
  • Amanda L Souza
  • Amy A Deik
  • Kerry A Pierce
  • Kevin Bullock
  • Christopher J O'Donnell
  • Olle Melander
  • Clary B Clish
  • Ramachandran S Vasan
  • Robert E Gerszten
  • Thomas J Wang

Summary, in English

Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death.

Department/s

  • Cardiovascular Research - Hypertension
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Publication/Series

Nature Communications

Volume

6

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Hypertension

ISBN/ISSN/Other

  • ISSN: 2041-1723