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Olle Melander

Principal investigator

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Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS).


  • D. Jönsson
  • M. Orho-Melander
  • R. T. Demmer
  • G. Engström
  • O. Melander
  • B. Klinge
  • P. M. Nilsson

Summary, in English

Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malmö Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.


  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

Publishing year







Journal of Internal Medicine





Document type

Journal article




  • Dentistry
  • Cardiac and Cardiovascular Systems
  • Public Health, Global Health, Social Medicine and Epidemiology


  • atherosclerosis
  • carotid plaque
  • epidemiology
  • periodontal disease



Research group

  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology


  • ISSN: 0954-6820