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Olle Melander

Principal investigator

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Telomere Length Is Associated With Obesity Parameters but With a Gender Difference

Author

  • Katarina Nordfjall
  • Mats Eliasson
  • Birgitta Stegmayr
  • Olle Melander
  • Peter Nilsson
  • Goran Roos

Summary, in English

Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = -0.106, P = 0.021, weight: r = -0.087, P = 0.060, waist circumference: r = -0.099, P = 0.032, hip circumference: r = -0.128, P = 0.005). In men, a positive borderline correlation to high-density lipoprotein (HDL) (r = 0.111, P = 0.053) and a negative correlation to 2-h post-oral glucose-tolerance test (OGTT) was observed (r = -0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low-density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an "obesity-phenotype" but only in women.

Department/s

  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

Publishing year

2008

Language

English

Pages

2682-2689

Publication/Series

Obesity

Volume

16

Issue

12

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Nutrition and Dietetics

Status

Published

Research group

  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1930-739X